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    Mar 04, 2021
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    Severe post-kala-azar dermal leishmaniasis successfully treated with miltefosine in an Ethiopian HIV patient.

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    Abongomera et al - 2019 - Severe ...
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    Authors
    Abongomera, C
    Battaglioli, T
    Adera, C
    Ritmeijer, K
    Issue Date
    2019-02-18
    Submitted date
    2019-02-25
    
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    Journal
    International Journal of Infectious Disease
    Abstract
    Post-kala-azar dermal leishmaniasis (PKDL) is a neglected tropical disease characterized by a dermatosis which often appears after successful treatment of visceral leishmaniasis caused by Leishmania donovani. PKDL treatment options are few and have severe limitations. In East- Africa, the standard treatment of PKDL is with daily painful potentially toxic sodium stibogluconate injections, administered for a prolonged duration of 30-60 days. In the Indian subcontinent, PKDL is mainly treated with miltefosine, a safer orally administered drug. However, in East-Africa, there is very limited experience in the use of miltefosine for treatment of severe PKDL, with only one published case report. Here we report a severe PKDL case in an Ethiopian HIV patient successfully treated with oral miltefosine (100 milligrams/day for 28 days). Miltefosine was efficacious, safe and well tolerated, suggesting that it can play an important role in the treatment of severe PKDL also in East-African patients. Further research is warranted.
    Publisher
    Elsevier
    URI
    http://hdl.handle.net/10144/619354
    DOI
    10.1016/j.ijid.2019.02.012
    PubMed ID
    30790722
    Language
    en
    ISSN
    1878-3511
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ijid.2019.02.012
    Scopus Count
    Collections
    Leishmaniasis/Kala Azar

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