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    Jan 19, 2021
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    2017 Outbreak of Ebola Virus Disease in Northern Democratic Republic of Congo

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    Nsio et al - 2019 - 2017 Outbreak ...
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    Authors
    Nsio, J
    Kapetshi, J
    Makiala, S
    Raymond, F
    Tshapenda, G
    Boucher, N
    Corbeil, J
    Okitandjate, A
    Mbuyi, G
    Kiyele, M
    Mondonge, V
    Kikoo, MJ
    Van Herp, M
    Barboza, P
    Petrucci, R
    Benedetti, G
    Formenty, P
    Muzinga, BM
    Kalenga, OI
    Ahuka, S
    Fausther-Bovendo, H
    Ilunga, BK
    Kobinger, GP
    Muyembe, JJT
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    Issue Date
    2019-04-03
    Submitted date
    2019-04-16
    
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    Journal
    Journal of Infectious Diseases
    Abstract
    Background In 2017, the Democratic Republic of the Congo (DRC) recorded its eighth Ebola virus disease (EVD) outbreak, approximately 3 years after the previous outbreak. Methods Suspect cases of EVD were identified on the basis of clinical and epidemiological information. Reverse transcription–polymerase chain reaction (RT-PCR) analysis or serological testing was used to confirm Ebola virus infection in suspected cases. The causative virus was later sequenced from a RT-PCR–positive individual and assessed using phylogenetic analysis. Results Three probable and 5 laboratory-confirmed cases of EVD were recorded between 27 March and 1 July 2017 in the DRC. Fifty percent of cases died from the infection. EVD cases were detected in 4 separate areas, resulting in > 270 contacts monitored. The complete genome of the causative agent, a variant from the Zaireebolavirus species, denoted Ebola virus Muyembe, was obtained using next-generation sequencing. This variant is genetically closest, with 98.73% homology, to the Ebola virus Mayinga variant isolated from the first DRC outbreaks in 1976–1977. Conclusion A single spillover event into the human population is responsible for this DRC outbreak. Human-to-human transmission resulted in limited dissemination of the causative agent, a novel Ebola virus variant closely related to the initial Mayinga variant isolated in 1976–1977 in the DRC.
    Publisher
    Oxford University Press
    URI
    http://hdl.handle.net/10144/619373
    Language
    en
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    Other Diseases

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