Show simple item record

dc.contributor.authorNsio, J*
dc.contributor.authorKapetshi, J*
dc.contributor.authorMakiala, S*
dc.contributor.authorRaymond, F*
dc.contributor.authorTshapenda, G*
dc.contributor.authorBoucher, N*
dc.contributor.authorCorbeil, J*
dc.contributor.authorOkitandjate, A*
dc.contributor.authorMbuyi, G*
dc.contributor.authorKiyele, M*
dc.contributor.authorMondonge, V*
dc.contributor.authorKikoo, MJ*
dc.contributor.authorVan Herp, M*
dc.contributor.authorBarboza, P*
dc.contributor.authorPetrucci, R*
dc.contributor.authorBenedetti, G*
dc.contributor.authorFormenty, P*
dc.contributor.authorMuzinga, BM*
dc.contributor.authorKalenga, OI*
dc.contributor.authorAhuka, S*
dc.contributor.authorFausther-Bovendo, H*
dc.contributor.authorIlunga, BK*
dc.contributor.authorKobinger, GP*
dc.contributor.authorMuyembe, JJT*
dc.date.accessioned2019-04-19T19:04:00Z
dc.date.available2019-04-19T19:04:00Z
dc.date.issued2019-04-03
dc.date.submitted2019-04-16
dc.identifier.urihttp://hdl.handle.net/10144/619373
dc.description.abstractBackground In 2017, the Democratic Republic of the Congo (DRC) recorded its eighth Ebola virus disease (EVD) outbreak, approximately 3 years after the previous outbreak. Methods Suspect cases of EVD were identified on the basis of clinical and epidemiological information. Reverse transcription–polymerase chain reaction (RT-PCR) analysis or serological testing was used to confirm Ebola virus infection in suspected cases. The causative virus was later sequenced from a RT-PCR–positive individual and assessed using phylogenetic analysis. Results Three probable and 5 laboratory-confirmed cases of EVD were recorded between 27 March and 1 July 2017 in the DRC. Fifty percent of cases died from the infection. EVD cases were detected in 4 separate areas, resulting in > 270 contacts monitored. The complete genome of the causative agent, a variant from the Zaireebolavirus species, denoted Ebola virus Muyembe, was obtained using next-generation sequencing. This variant is genetically closest, with 98.73% homology, to the Ebola virus Mayinga variant isolated from the first DRC outbreaks in 1976–1977. Conclusion A single spillover event into the human population is responsible for this DRC outbreak. Human-to-human transmission resulted in limited dissemination of the causative agent, a novel Ebola virus variant closely related to the initial Mayinga variant isolated in 1976–1977 in the DRC.en_US
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.rightsWith thanks to Oxford University Press.en_US
dc.title2017 Outbreak of Ebola Virus Disease in Northern Democratic Republic of Congoen_US
dc.identifier.journalJournal of Infectious Diseasesen_US
refterms.dateFOA2019-04-19T19:04:00Z


Files in this item

Thumbnail
Name:
Nsio et al - 2019 - 2017 Outbreak ...
Size:
366.6Kb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record