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dc.contributor.authorNsio, J
dc.contributor.authorKapetshi, J
dc.contributor.authorMakiala, S
dc.contributor.authorRaymond, F
dc.contributor.authorTshapenda, G
dc.contributor.authorBoucher, N
dc.contributor.authorCorbeil, J
dc.contributor.authorOkitandjate, A
dc.contributor.authorMbuyi, G
dc.contributor.authorKiyele, M
dc.contributor.authorMondonge, V
dc.contributor.authorKikoo, MJ
dc.contributor.authorVan Herp, M
dc.contributor.authorBarboza, P
dc.contributor.authorPetrucci, R
dc.contributor.authorBenedetti, G
dc.contributor.authorFormenty, P
dc.contributor.authorMuzinga, BM
dc.contributor.authorKalenga, OI
dc.contributor.authorAhuka, S
dc.contributor.authorFausther-Bovendo, H
dc.contributor.authorIlunga, BK
dc.contributor.authorKobinger, GP
dc.contributor.authorMuyembe, JJT
dc.date.accessioned2019-04-19T19:04:00Z
dc.date.available2019-04-19T19:04:00Z
dc.date.issued2019-04-03
dc.date.submitted2019-04-16
dc.identifier.urihttp://hdl.handle.net/10144/619373
dc.description.abstractBackground In 2017, the Democratic Republic of the Congo (DRC) recorded its eighth Ebola virus disease (EVD) outbreak, approximately 3 years after the previous outbreak. Methods Suspect cases of EVD were identified on the basis of clinical and epidemiological information. Reverse transcription–polymerase chain reaction (RT-PCR) analysis or serological testing was used to confirm Ebola virus infection in suspected cases. The causative virus was later sequenced from a RT-PCR–positive individual and assessed using phylogenetic analysis. Results Three probable and 5 laboratory-confirmed cases of EVD were recorded between 27 March and 1 July 2017 in the DRC. Fifty percent of cases died from the infection. EVD cases were detected in 4 separate areas, resulting in > 270 contacts monitored. The complete genome of the causative agent, a variant from the Zaireebolavirus species, denoted Ebola virus Muyembe, was obtained using next-generation sequencing. This variant is genetically closest, with 98.73% homology, to the Ebola virus Mayinga variant isolated from the first DRC outbreaks in 1976–1977. Conclusion A single spillover event into the human population is responsible for this DRC outbreak. Human-to-human transmission resulted in limited dissemination of the causative agent, a novel Ebola virus variant closely related to the initial Mayinga variant isolated in 1976–1977 in the DRC.en_US
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.rightsWith thanks to Oxford University Press.en_US
dc.title2017 Outbreak of Ebola Virus Disease in Northern Democratic Republic of Congoen_US
dc.identifier.journalJournal of Infectious Diseasesen_US
refterms.dateFOA2019-04-19T19:04:00Z


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