• Login
    View Item 
    •   Home
    • 1 Published Research and Commentary
    • Other Diseases
    • View Item
    •   Home
    • 1 Published Research and Commentary
    • Other Diseases
    • View Item
    Apr 18, 2021
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of MSFTitleAuthorsSubjectsPublisherJournalThis CollectionTitleAuthorsSubjectsPublisherJournal

    Molecular epidemiology of hepatitis C virus in Cambodia during 2016-2017.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Nouhin et al - 2019 - Molecular ...
    Size:
    1.770Mb
    Format:
    PDF
    Download
    Authors
    Nouhin, J
    Iwamoto, M
    Prak, S
    Dousset, JP
    Phon, K
    Heng, S
    Kerleguer, A
    Le Paih, M
    Dussart, P
    Maman, D
    Rouet, F
    Show allShow less
    Issue Date
    2019-05-13
    Submitted date
    2019-05-30
    
    Metadata
    Show full item record
    Journal
    Scientific Reports
    Abstract
    In Cambodia, little epidemiological data of hepatitis C virus (HCV) is available. All previous studies were limited to only small or specific populations. In the present study, we performed a characterization of HCV genetic diversity based on demography, clinical data, and phylogenetic analysis of HCV non-structural 5B (NS5B) sequences belonging to a large cohort of patients (n = 3,133) coming from majority part of Cambodia between September 2016 and December 2017. The phylogenetic analysis revealed that HCV genotype 1 and 6 were the most predominant and sharing equal proportions (46%). The remaining genotypes were genotype 2 (4.3%) and unclassified variants (3.6%). Among genotype 1, subtype 1b was the most prevalent subtype accounting for 94%. Within genotype 6, we observed a high degree of diversity and the most common viral subtypes were 6e (44%) and 6r (23%). This characteristic points to the longstanding history of HCV in Cambodia. Geographic specificity of viral genotype was not observed. Risks of HCV infection were mainly associated with experience of an invasive medical procedure (64.7%), having partner with HCV (19.5%), and blood transfusion (9.9%). In addition, all of these factors were comparable among different HCV genotypes. All these features define the specificity of HCV epidemiology in Cambodia.
    Publisher
    Nature Publishing Group
    URI
    http://hdl.handle.net/10144/619392
    DOI
    10.1038/s41598-019-43785-4
    PubMed ID
    31086236
    Language
    en
    ISSN
    2045-2322
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41598-019-43785-4
    Scopus Count
    Collections
    Other Diseases

    entitlement

    Related articles

    • Use of sequence analysis of the NS5B region for routine genotyping of hepatitis C virus with reference to C/E1 and 5' untranslated region sequences.
    • Authors: Murphy DG, Willems B, Deschênes M, Hilzenrat N, Mousseau R, Sabbah S
    • Issue date: 2007 Apr
    • Hepatitis C Genotype Prevalence in Monastir Region, Tunisia: Correlation between 5' Untranslated Region (5'UTR), Non-structural 5B (NS5B), and Core Sequences in HCV Subtyping.
    • Authors: Souii A, Elargoubi A, Fallecker C, Mastouri M, Drouet E
    • Issue date: 2016 Sep
    • Phylogenetic analysis of hepatitis C virus strains and risk factors associated with infection and viral subtypes among Iranian patients.
    • Authors: Salehi Moghadam F, Mohebbi SR, Hosseini SM, Romani S, Mirtalebi H, Azimzadeh P, Damavand B, Naghoosi H, Khanyaghma M, Sanati A, Zali MR
    • Issue date: 2014 Aug
    • Molecular epidemiology and genetic history of hepatitis C virus subtype 3a infection in Thailand.
    • Authors: Akkarathamrongsin S, Hacharoen P, Tangkijvanich P, Theamboonlers A, Tanaka Y, Mizokami M, Poovorawan Y
    • Issue date: 2013
    • Global epidemiology of HCV subtypes and resistance-associated substitutions evaluated by sequencing-based subtype analyses.
    • Authors: Welzel TM, Bhardwaj N, Hedskog C, Chodavarapu K, Camus G, McNally J, Brainard D, Miller MD, Mo H, Svarovskaia E, Jacobson I, Zeuzem S, Agarwal K
    • Issue date: 2017 Aug
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.