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dc.contributor.authorNouhin, J
dc.contributor.authorIwamoto, M
dc.contributor.authorPrak, S
dc.contributor.authorDousset, JP
dc.contributor.authorPhon, K
dc.contributor.authorHeng, S
dc.contributor.authorKerleguer, A
dc.contributor.authorLe Paih, M
dc.contributor.authorDussart, P
dc.contributor.authorMaman, D
dc.contributor.authorRouet, F
dc.date.accessioned2019-06-25T14:58:36Z
dc.date.available2019-06-25T14:58:36Z
dc.date.issued2019-05-13
dc.date.submitted2019-05-30
dc.identifier.issn2045-2322
dc.identifier.pmid31086236
dc.identifier.doi10.1038/s41598-019-43785-4
dc.identifier.urihttp://hdl.handle.net/10144/619392
dc.description.abstractIn Cambodia, little epidemiological data of hepatitis C virus (HCV) is available. All previous studies were limited to only small or specific populations. In the present study, we performed a characterization of HCV genetic diversity based on demography, clinical data, and phylogenetic analysis of HCV non-structural 5B (NS5B) sequences belonging to a large cohort of patients (n = 3,133) coming from majority part of Cambodia between September 2016 and December 2017. The phylogenetic analysis revealed that HCV genotype 1 and 6 were the most predominant and sharing equal proportions (46%). The remaining genotypes were genotype 2 (4.3%) and unclassified variants (3.6%). Among genotype 1, subtype 1b was the most prevalent subtype accounting for 94%. Within genotype 6, we observed a high degree of diversity and the most common viral subtypes were 6e (44%) and 6r (23%). This characteristic points to the longstanding history of HCV in Cambodia. Geographic specificity of viral genotype was not observed. Risks of HCV infection were mainly associated with experience of an invasive medical procedure (64.7%), having partner with HCV (19.5%), and blood transfusion (9.9%). In addition, all of these factors were comparable among different HCV genotypes. All these features define the specificity of HCV epidemiology in Cambodia.en_US
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.rightsWith thanks to Nature Publishing Group.en_US
dc.titleMolecular epidemiology of hepatitis C virus in Cambodia during 2016-2017.en_US
dc.identifier.journalScientific Reportsen_US
dc.source.journaltitleScientific reports
refterms.dateFOA2019-06-25T14:58:36Z


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