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    Jan 23, 2021
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    The STREAM trial: missed opportunities and lessons for future clinical trials.

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    Loveday et al - 2019 - The STREAM ...
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    Authors
    Loveday, M
    Reuter, A
    Furin, J
    Seddon, JA
    Cox, H
    Issue Date
    2019-04-01
    Submitted date
    2019-05-30
    
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    Journal
    Lancet Infectious Diseases
    Abstract
    Final results of the STREAM trial were presented at the 2018, 49th Union World Conference on Lung Health, held in The Hague, The Netherlands. STREAM is a randomised controlled trial comparing the 18–24 month WHO-recommended multidrug-resistant tuberculosis (MDR-TB) treatment regimen with a 9–12 month regimen similar to that first described in Bangladesh. 1 Under programmatic conditions, the longer regimen results in treatment success for approximately 50% of patients, 2 whereas the shorter 9–12 month regimen improved treatment success to 80% or higher in selected countries. 3 , 4 Because these countries had relatively low HIV prevalence and relatively high percentages of treatment success with the longer regimens, questions around generalisability were raised. 4 STREAM was a multi-million dollar undertaking that took almost 10 years from the time of study design until the release of final results. Given the time and costs involved it is essential to reflect on lessons learned, and what the trial results tell us to inform how we accumulate future evidence to guide MDR-TB treatment.
    Publisher
    Elsevier
    URI
    http://hdl.handle.net/10144/619399
    DOI
    10.1016/S1473-3099(19)30106-9
    PubMed ID
    30910428
    Language
    en
    ISSN
    1474-4457
    ae974a485f413a2113503eed53cd6c53
    10.1016/S1473-3099(19)30106-9
    Scopus Count
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    Research Methods

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