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dc.contributor.authorRoddy, P
dc.contributor.authorDalrymple, U
dc.contributor.authorJensen, TO
dc.contributor.authorDittrich, S
dc.contributor.authorRao, VB
dc.contributor.authorPfeffer, DA
dc.contributor.authorTwohig, KA
dc.contributor.authorRoberts, T
dc.contributor.authorBernal, O
dc.contributor.authorGuillen, E
dc.date.accessioned2019-08-20T16:35:55Z
dc.date.available2019-08-20T16:35:55Z
dc.date.issued2019-07-25
dc.date.submitted2019-08-15
dc.identifier.issn1932-6203
dc.identifier.pmid31344116
dc.identifier.doi10.1371/journal.pone.0220371
dc.identifier.urihttp://hdl.handle.net/10144/619452
dc.description.abstractSevere-febrile-illness (SFI) is a common cause of morbidity and mortality across sub-Saharan Africa (SSA). The burden of SFI in SSA is currently unknown and its estimation is fraught with challenges. This is due to a lack of diagnostic capacity for SFI in SSA, and thus a dearth of baseline data on the underlying etiology of SFI cases and scant SFI-specific causative-agent prevalence data. To highlight the public health significance of SFI in SSA, we developed a Bayesian model to quantify the incidence of SFI hospital admissions in SSA. Our estimates indicate a mean population-weighted SFI-inpatient-admission incidence rate of 18.4 (6.8-31.1, 68% CrI) per 1000 people for the year 2014, across all ages within areas of SSA with stable Plasmodium falciparum transmission. We further estimated a total of 16,200,337 (5,993,249-27,321,779, 68% CrI) SFI hospital admissions. This analysis reveals the significant burden of SFI in hospitals in SSA, but also highlights the paucity of pathogen-specific prevalence and incidence data for SFI in SSA. Future improvements in pathogen-specific diagnostics for causative agents of SFI will increase the abundance of SFI-specific prevalence and incidence data, aid future estimations of SFI burden, and enable clinicians to identify SFI-specific pathogens, administer appropriate treatment and management, and facilitate appropriate antibiotic use.en_US
dc.language.isoenen_US
dc.publisherPublic Library of Scienceen_US
dc.rightsWith thanks to the Public Library of Science.en_US
dc.titleQuantifying the incidence of severe-febrile-illness hospital admissions in sub-Saharan Africa.en_US
dc.identifier.journalPLoS Oneen_US
dc.source.journaltitlePloS one
refterms.dateFOA2019-08-20T16:35:55Z


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