Show simple item record

dc.contributor.authorBastard, M
dc.contributor.authorSanchez-Padilla, E
dc.contributor.authorHayrapetyan, A
dc.contributor.authorKimenye, K
dc.contributor.authorKhurkhumal, S
dc.contributor.authorDlamini, T
dc.contributor.authorFadul Perez, S
dc.contributor.authorTelnov, A
dc.contributor.authorHewison, C
dc.contributor.authorVaraine, F
dc.contributor.authorBonnet, M
dc.date.accessioned2019-11-12T12:58:14Z
dc.date.available2019-11-12T12:58:14Z
dc.date.issued2019-10-01
dc.date.submitted2019-11-08
dc.identifier.urihttp://hdl.handle.net/10144/619504
dc.description.abstractINTRODUCTION: Identification of good prognostic marker for tuberculosis (TB) treatment response is a necessary step on the path towards a surrogate marker to reduce TB trial duration. METHODS: We performed a retrospective analysis on routinely collected data in 6 drug-resistant TB (DRTB) programs. Culture conversion, defined as two consecutive negative cultures, was assessed, and performance of culture conversion at Month 2 and Month 6 to predict treatment success were explored. To explore factors associated with positive predicted value (PPV) and the specificity of culture conversion, a multinomial logistic regression was fitted. RESULTS: This study included 634 patients: 68.5% were males; the median age was 35 years, 75.2% were previously treated for TB, 59.4% were resistant only to isoniazid and rifampicin and 18.1% resistant to fluoroquinolones. Culture conversion at Month 2 and 6 showed similar PPV while specificity was much higher for culture conversion at Month 2: 91.3% (95%CI 86.1–95.1). PPV of culture conversion at Month 2 did not vary strongly according to patients' characteristics, while specificity was slightly higher among patients with fluoroquinolone-resistant strains. CONCLUSION: Culture conversion at Month 2 is an acceptable prognostic marker for MDR-TB treatment. Considering the advantage of using an earlier marker, further evaluation as a surrogate marker is warranted to shorten TB trials.en_US
dc.language.isoenen_US
dc.publisherInternational Union Against Tuberculosis and Lung Diseaseen_US
dc.rightsWith thanks to the International Union Against Tuberculosis and Lung Disease.en_US
dc.titleWhat is the best culture conversion prognostic marker for patients treated for multidrug-resistant tuberculosis?en_US
dc.identifier.journalInternational Journal of Tuberculosis and Lung Diseaseen_US
refterms.dateFOA2019-11-12T12:58:15Z


Files in this item

Thumbnail
Name:
Bastard et al 2019 What is the ...
Size:
350.3Kb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record