• Login
    View Item 
    •   Home
    • 1 Published Research and Commentary
    • Other Diseases
    • View Item
    •   Home
    • 1 Published Research and Commentary
    • Other Diseases
    • View Item
    Jan 26, 2021
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of MSFTitleAuthorsSubjectsPublisherJournalThis CollectionTitleAuthorsSubjectsPublisherJournal

    Paediatric Buruli ulcer in Australia

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Walker et al 2019 Paediatric ...
    Size:
    149.6Kb
    Format:
    PDF
    Download
    Thumbnail
    Name:
    Walker et al 2019 Paediatric ...
    Size:
    149.6Kb
    Format:
    PDF
    Download
    Authors
    Walker, G
    Friedman, D
    Cooper, C
    O'Brien, M
    McDonald, A
    Callan, P
    O'Brien, D
    Affiliation
    MSF UK Manson Unit
    Issue Date
    2019-12-10
    Submitted date
    2019-12
    
    Metadata
    Show full item record
    Journal
    Journal Paediatric Child Health
    Abstract
    AIM: This study describes an Australian cohort of paediatric Buruli ulcer (BU) patients and compares them with adult BU patients. METHODS: Analysis of a prospective cohort of all BU cases managed at Barwon Health, Victoria, from 1 January 1998 to 31 May 2018 was performed. Children were defined as ≤15 years of age. RESULTS: A total of 565 patients were included: 52 (9.2%) children, 289 (51.2%) adults aged 16-64 years and 224 (39.6%) adults aged ≥65 years. Among children, half were female and the median age was 8.0 years (interquartile range 4.8-12.3 years). Six (11.5%) cases were diagnosed from 2001 to 2006, 14 (26.9%) from 2007 to 2012 and 32 (61.5%) from 2013 to 2018. Compared to adults, children had a significantly higher proportion of non-ulcerative lesions (32.7%, P < 0.001) and a higher proportion of severe lesions (26.9%, P < 0.01). The median duration of symptoms prior to diagnosis was shorter for children compared with adults aged 16-64 years (42 vs. 56 days, P = 0.04). Children were significantly less likely to experience antibiotic complications (6.1%) compared with adults (20.6%, P < 0.001), but had a significantly higher rate of paradoxical reactions (38.8%) compared with adults aged 16-64 (19.2%) (P < 0.001). Paradoxical reactions in children occurred significantly earlier than in adults (median 17 vs. 56 days, P < 0.01). Cure rates were similarly high for children compared to adults treated with antibiotics alone or with antibiotics and surgery. CONCLUSIONS: Paediatric BU cases in Australia are increasing and represent an important but stable proportion of Australian BU cohorts. Compared with adults, there are significant differences in clinical presentation and treatment outcomes.
    URI
    http://hdl.handle.net/10144/619557
    DOI
    10.1111/jpc.14704
    PubMed ID
    31821679
    Language
    en
    ISSN
    1440-1754
    ae974a485f413a2113503eed53cd6c53
    10.1111/jpc.14704
    Scopus Count
    Collections
    Other Diseases

    entitlement

    Related articles

    • Increasing Experience with Primary Oral Medical Therapy for Mycobacterium ulcerans Disease in an Australian Cohort.
    • Authors: Friedman ND, Athan E, Walton AL, O'Brien DP
    • Issue date: 2016 May
    • Wound healing: Natural history and risk factors for delay in Australian patients treated with antibiotics for Mycobacterium ulcerans disease.
    • Authors: O'Brien DP, Friedman ND, McDonald A, Callan P, Hughes A, Walton A, Athan E
    • Issue date: 2018 Mar
    • Incidence, clinical spectrum, diagnostic features, treatment and predictors of paradoxical reactions during antibiotic treatment of Mycobacterium ulcerans infections.
    • Authors: O'Brien DP, Robson M, Friedman ND, Walton A, McDonald A, Callan P, Hughes A, Rahdon R, Athan E
    • Issue date: 2013 Sep 5
    • Mycobacterium ulcerans in the Elderly: More Severe Disease and Suboptimal Outcomes.
    • Authors: O'Brien DP, Friedman ND, Cowan R, Pollard J, McDonald A, Callan P, Hughes A, Athan E
    • Issue date: 2015 Dec
    • Buruli ulcer in Nigeria: results of a pilot case study in three rural districts.
    • Authors: Ukwaja KN, Meka AO, Chukwuka A, Asiedu KB, Huber KL, Eddyani M, Chukwu JN, Anyim MC, Nwafor CC, Oshi DC, Madichie NO, Ekeke N, Njoku M, Ntana K
    • Issue date: 2016 Apr 22
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.