Tuberculosis-HIV Co-Infection: Progress and Challenges After Two Decades of Global Antiretroviral Treatment Roll-Out.
Authors
Letang, EEllis, J
Naidoo, K
Casas, EC
Sanchez, P
Hassan-Moosa, R
Cresswell, F
Miro, JM
Garcia-Basteiro, AL
Issue Date
2020-01-10Submitted date
2020-01-27
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Archivos de BronconeumologíaAbstract
Despite wide antiretroviral scale-up during the past two decades resulting in declining new infections and mortality globally, HIV-associated tuberculosis remains as a major public health concern. Tuberculosis is the leading HIV-associated opportunistic infection and the main cause of death globally and, particularly, in resource-limited settings. Several challenges exist regarding diagnosis, global implementation of latent tuberculosis treatment, management of active tuberculosis, delivery of optimal patient-centered TB and HIV prevention and care in high burden countries. In this article we review the advances on pathogenesis, diagnosis, and treatment after nearly two decades of global roll-out of antiretroviral therapy and discuss the current challenges for the global control of tuberculosis-HIV co-infection.Publisher
ElsevierPubMed ID
31932150Language
enISSN
1579-2129ae974a485f413a2113503eed53cd6c53
10.1016/j.arbres.2019.11.015
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