MDR/XDR-TB management of patients and contacts: challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network.
Authors
Battista Migliori, GTiberi, S
Zumla, A
Petersen, E
Muhwa Chakaya, J
Wejse, C
Muñoz Torrico, M
Duarte, R
Alffenaar, JW
Schaaf, HS
Marais, BJ
Cirillo, DM
Alagna, R
Rendon, A
Pontali, E
Piubello, A
Figueroa, J
Ferlazzo, G
García-Basteiro, A
Centis, R
Visca, D
D'Ambrosio, L
Sotgiu, G
Issue Date
2020-02-04Submitted date
2020-02-14
Metadata
Show full item recordAbstract
The continuous flow of new research articles on MDR-TB diagnosis, treatment, prevention and rehabilitation requires frequent update of existing guidelines. This review is aimed at providing clinicians and public health staff with an updated and easy-to-consult document arising from consensus of Global Tuberculosis Network (GTN) experts. The core published documents and guidelines have been reviewed including the recently published MDR-TB WHO rapid advice and ATS/CDC/ERS/IDSA guidelines. After a rapid review of epidemiology and risk factors, the clinical priorities on MDR-TB diagnosis (including whole genome sequencing and drug-susceptibility testing interpretations) and treatment (treatment design and management, TB in children) are discussed. Furthermore, the review comprehensively describes the latest information on contact tracing and LTBI management in MDR-TB contacts, while providing guidance on post-treatment functional evaluation and rehabilitation of TB sequelae, infection control and other public health priorities.Publisher
ElsevierPubMed ID
32032752Language
enISSN
1878-3511ae974a485f413a2113503eed53cd6c53
10.1016/j.ijid.2020.01.042