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    Apr 10, 2021
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    MDR/XDR-TB management of patients and contacts: challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network.

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    Authors
    Battista Migliori, G
    Tiberi, S
    Zumla, A
    Petersen, E
    Muhwa Chakaya, J
    Wejse, C
    Muñoz Torrico, M
    Duarte, R
    Alffenaar, JW
    Schaaf, HS
    Marais, BJ
    Cirillo, DM
    Alagna, R
    Rendon, A
    Pontali, E
    Piubello, A
    Figueroa, J
    Ferlazzo, G
    García-Basteiro, A
    Centis, R
    Visca, D
    D'Ambrosio, L
    Sotgiu, G
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    Issue Date
    2020-02-04
    Submitted date
    2020-02-14
    
    Metadata
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    Journal
    International Journal of Infectious Diseases
    Abstract
    The continuous flow of new research articles on MDR-TB diagnosis, treatment, prevention and rehabilitation requires frequent update of existing guidelines. This review is aimed at providing clinicians and public health staff with an updated and easy-to-consult document arising from consensus of Global Tuberculosis Network (GTN) experts. The core published documents and guidelines have been reviewed including the recently published MDR-TB WHO rapid advice and ATS/CDC/ERS/IDSA guidelines. After a rapid review of epidemiology and risk factors, the clinical priorities on MDR-TB diagnosis (including whole genome sequencing and drug-susceptibility testing interpretations) and treatment (treatment design and management, TB in children) are discussed. Furthermore, the review comprehensively describes the latest information on contact tracing and LTBI management in MDR-TB contacts, while providing guidance on post-treatment functional evaluation and rehabilitation of TB sequelae, infection control and other public health priorities.
    Publisher
    Elsevier
    URI
    http://hdl.handle.net/10144/619606
    DOI
    10.1016/j.ijid.2020.01.042
    PubMed ID
    32032752
    Language
    en
    ISSN
    1878-3511
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ijid.2020.01.042
    Scopus Count
    Collections
    TB

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