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dc.contributor.authorFerreras, E
dc.contributor.authorBlake, A
dc.contributor.authorChewe, O
dc.contributor.authorMwaba, J
dc.contributor.authorZulu, G
dc.contributor.authorPoncin, M
dc.contributor.authorRakesh, A
dc.contributor.authorPage, AL
dc.contributor.authorQuilici, ML
dc.contributor.authorAzman, AS
dc.contributor.authorCohuet, S
dc.contributor.authorCiglenecki, I
dc.contributor.authorMalama, K
dc.contributor.authorChizema-Kawesha, E
dc.contributor.authorLuquero, FJ
dc.date.accessioned2020-06-23T19:12:20Z
dc.date.available2020-06-23T19:12:20Z
dc.date.issued2020-03-13
dc.date.submitted2020-04-17
dc.identifier.pmid32167038
dc.identifier.doi10.1017/S095026882000062X
dc.identifier.urihttp://hdl.handle.net/10144/619645
dc.description.abstractWe conducted a matched case-control (MCC), test-negative case-control (TNCC) and case-cohort study in 2016 in Lusaka, Zambia, following a mass vaccination campaign. Confirmed cholera cases served as cases in all three study designs. In the TNCC, control-subjects were cases with negative cholera culture and polymerase chain reaction results. Matched controls by age and sex were selected among neighbours of the confirmed cases in the MCC study. For the case-cohort study, we recruited a cohort of randomly selected individuals living in areas considered at-risk of cholera. We recruited 211 suspected cases (66 confirmed cholera cases and 145 non-cholera diarrhoea cases), 1055 matched controls and a cohort of 921. Adjusted vaccine effectiveness of one dose of oral cholera vaccine (OCV) was 88.9% (95% confidence interval (CI) 42.7-97.8) in the MCC study, 80.2% (95% CI: 16.9-95.3) in the TNCC design and 89.4% (95% CI: 64.6-96.9) in the case-cohort study. Three study designs confirmed the short-term effectiveness of single dose OCV. Major healthcare-seeking behaviour bias did not appear to affect our estimates. Most of the protection among vaccinated individuals could be attributed to the direct effect of the vaccine.en_US
dc.language.isoenen_US
dc.publisherCambridge University Pressen_US
dc.rightsWith thanks to Cambridge University Press.en_US
dc.subjectCholera
dc.subjectinfectious disease epidemiology
dc.subjectpublic health
dc.subjectvaccine policy development
dc.titleAlternative observational designs to estimate the effectiveness of one dose of oral cholera vaccine in Lusaka, Zambiaen_US
dc.typeArticle
dc.identifier.eissn1469-4409
dc.identifier.journalEpidemiology and Infectionen_US
dc.source.journaltitleEpidemiology and infection
dc.source.volume148
dc.source.beginpagee78
dc.source.endpage
refterms.dateFOA2020-06-23T19:12:20Z
dc.source.countryEngland


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