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dc.contributor.authorParyani, RH
dc.contributor.authorGupta, V
dc.contributor.authorSingh, P
dc.contributor.authorVerma, M
dc.contributor.authorSheikh, S
dc.contributor.authorYadav, R
dc.contributor.authorMansoor, H
dc.contributor.authorKalon, S
dc.contributor.authorSelvaraju, S
dc.contributor.authorDas, M
dc.contributor.authorLaxmeshwar, C
dc.contributor.authorFerlazzo, G
dc.contributor.authorIsaakidis, P
dc.date.accessioned2020-07-11T22:52:48Z
dc.date.available2020-07-11T22:52:48Z
dc.date.issued2020-05-26
dc.date.submitted2020-07-10
dc.identifier.pmid32466438
dc.identifier.doi10.3390/tropicalmed5020083
dc.identifier.urihttp://hdl.handle.net/10144/619672
dc.description.abstractWhile risk of tuberculosis (TB) is high among household contacts (HHCs) of pre-extensively drug resistant (pre-XDR) TB and XDR-TB, data on yield of systematic longitudinal screening are lacking. We aim to describe the yield of systematic longitudinal TB contact tracing among HHCs of patients with pre-XDR-TB and XDR-TB. At the Médecins Sans Frontières (MSF) clinic, Mumbai, India a cohort comprising 518 HHCs of 109 pre-XDR and XDR index cases was enrolled between January 2016 and June 2018. Regular HHC follow-ups were done till one year post treatment of index cases. Of 518 HHCs, 23 had TB (21 on TB treatment and two newly diagnosed) at the time of first visit. Of the rest, 19% HHCs had no follow-ups. Fourteen (3.5%) TB cases were identified among 400 HHCs; incidence rate: 2072/100,000 person-years (95% CI: 1227-3499). The overall yield of household contact tracing was 3% (16/518). Of 14 who were diagnosed with TB during follow-up, six had drug susceptible TB (DSTB); six had pre-XDR-TB and one had XDR-TB. Five of fourteen cases had resistance patterns concordant with their index case. In view of the high incidence of TB among HHCs of pre-XDR and XDR-TB cases, follow-up of HHCs for at least the duration of index cases' treatment should be considered.en_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.rightsWith thanks to MDPI.en_US
dc.subjecthousehold contacts tracing
dc.subjectincidence
dc.subjectoperational research
dc.subjecttuberculosis
dc.titleYield of Systematic Longitudinal Screening of Household Contacts of Pre-Extensively Drug Resistant (PreXDR) and Extensively Drug Resistant (XDR) Tuberculosis Patients in Mumbai, Indiaen_US
dc.typeArticle
dc.identifier.eissn2414-6366
dc.identifier.journalTropical Medicine and Infectious Diseaseen_US
dc.source.journaltitleTropical medicine and infectious disease
dc.source.volume5
dc.source.issue2
refterms.dateFOA2020-07-11T22:52:48Z
dc.source.countrySwitzerland


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