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    Jan 26, 2021
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    Acute respiratory failure in an infant and thiamine deficiency in West Africa: a case report

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    Hiffler et al 2020 Acute respi ...
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    Authors
    Hiffler, L
    Escajadillo, K
    Rocaspana, M
    Janet, S
    Issue Date
    2020-06-25
    Submitted date
    2020-07-17
    
    Metadata
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    Journal
    Oxford Medical Case Reports
    Abstract
    In paediatrics, the overall clinical picture of thiamine deficiency (TD) is not easy to recognize, because it mimics or can be confused with other diseases even in cases of classic beriberi. Unsurprisingly, the likelihood of misdiagnosis of TD is even greater where beriberi has not been described. Critically ill patients have increased thiamine body consumption and dextrose-based IV fluid increases thiamine cellular demand even further. Consequently, severe acute conditions may result in TD, or trigger TD signs in patients with borderline thiamine status, with life-threatening consequences. Here, we describe the case of a young patient admitted to a West African hospital where TD is not well documented and diagnosed with severe pneumonia who responded dramatically to thiamine injection. The lack of rapid diagnostic capacity and the severe outcome of TD justify the use of a therapeutic thiamine challenge in cases with high clinical suspicion. Increased awareness about TD and low threshold for thiamine use should guide clinicians in their practice.
    Publisher
    Oxford University Press
    URI
    http://hdl.handle.net/10144/619705
    DOI
    10.1093/omcr/omaa041
    PubMed ID
    32617168
    Type
    Other
    Language
    en
    ISSN
    2053-8855
    ae974a485f413a2113503eed53cd6c53
    10.1093/omcr/omaa041
    Scopus Count
    Collections
    Paediatrics

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