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    Apr 23, 2021
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    Humoral and cellular immune response induced by rVSVΔG-ZEBOV-GP vaccine among frontline workers during the 2013-2016 West Africa Ebola outbreak in Guinea

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    Boum et al 2020 Humoral and ...
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    Authors
    Boum, Y
    Juan-Giner, A
    Hitchings, M
    Soumah, A
    Strecker, T
    Sadjo, M
    Cuthbertson, H
    Hayes, P
    Tchaton, M
    Jemmy, JP
    Clarck, C
    King, D
    Faga, EM
    Becker, S
    Halis, B
    Gunnstein, N
    Carroll, M
    Røttingen, JA
    Kondé, MK
    Doumbia, M
    Henao-Restrepo, AM
    Kieny, MP
    Cisse, M
    Draguez, B
    Grais, RFF
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    Issue Date
    2020-06-26
    Submitted date
    2020-07-25
    
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    Journal
    Vaccine
    Abstract
    Background As part of a Phase III trial with the Ebola vaccine rVSVΔG-ZEBOV-GP in Guinea, we invited frontline workers (FLWs) to participate in a sub-study to provide additional information on the immunogenicity of the vaccine. Methods We conducted an open‐label, non‐randomized, single-arm immunogenicity evaluation of one dose of rVSVΔG-ZEBOV-GP among healthy FLWs in Guinea. FLWs who refused vaccination were offered to participate as a control group. We followed participants for 84 days with a subset followed-up for 180 days. The primary endpoint was immune response, as measured by ELISA for ZEBOV-glycoprotein–specific antibodies (ELISA-GP) at 28 days. We also conducted neutralization, whole virion ELISA and enzyme-linked immunospot (ELISPOT) assay for cellular response. Results A total of 1172 participants received one dose of vaccine and were followed-up for 84 days, among them 114 participants were followed-up for 180 days. Additionally, 99 participants were included in the control group and followed up for 180 days. Overall, 86.4% (95% CI 84.1–88.4) of vaccinated participants seroresponded at 28 days post-vaccination (ELISA- GP) with 65% of these seroresponding at 14 days post-vaccination. Among those who seroresponded at 28 days, 90.7% (95% CI 82.0–95.4) were still seropositive at 180 days. The proportion of seropositivity in the unvaccinated group was 0.0% (95% CI 0.0–3.8) at 28 days and 5.4% (95% CI 2.1–13.1) at 180 days post-vaccination. We found weak correlation between ELISA-GP and neutralization at baseline but significant pairwise correlation at 28 days post-vaccination. Among samples analysed for cellular response, only 1 (2.2%) exhibited responses towards the Zaire Ebola glycoprotein (Ebola GP ≥ 10) at baseline, 10 (13.5%) at day 28 post-vaccination and 27 (48.2%) at Day 180. Conclusions We found one dose of rVSVΔG-ZEBOV-GP to be highly immunogenic at 28- and 180-days post vaccination among frontline workers in Guinea. We also found a cellular response that increased with time.
    Publisher
    Elsevier
    URI
    http://hdl.handle.net/10144/619707
    DOI
    10.1016/j.vaccine.2020.04.066
    PubMed ID
    32499066
    Type
    Article
    Language
    en
    EISSN
    1873-2518
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.vaccine.2020.04.066
    Scopus Count
    Collections
    Ebola

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