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dc.contributor.authorGrandesso, F
dc.contributor.authorKasambara, W
dc.contributor.authorPage, AL
dc.contributor.authorDebes, AK
dc.contributor.authorM'bang'ombe, M
dc.contributor.authorPalomares, A
dc.contributor.authorLechevalier, P
dc.contributor.authorPezzoli, L
dc.contributor.authorAlley, I
dc.contributor.authorSalumu, L
dc.contributor.authorMsyamboza, K
dc.contributor.authorSack, D
dc.contributor.authorCohuet, S
dc.contributor.authorLuquero, FJ
dc.date.accessioned2020-08-10T18:39:12Z
dc.date.available2020-08-10T18:39:12Z
dc.date.issued2019-06-19
dc.date.submitted2020-07-25
dc.identifier.pmid31133470
dc.identifier.doi10.1016/j.vaccine.2019.05.044
dc.identifier.urihttp://hdl.handle.net/10144/619717
dc.description.abstractBackground: In response to a cholera outbreak among mobile, difficult-to-reach fishermen on Lake Chilwa, Malawi in 2016, a novel vaccine distribution strategy exploited the proven vaccine thermostability. Fishermen, while taking the first vaccine dose under supervision, received the second dose in a sealed bag, and were told to drink it two weeks later. This study assessed short-term vaccine protection of this strategy. Methods: Patients with diarrhoea admitted to health facilities around lake were interviewed and a stool sample collected for PCR testing. Vaccine effectiveness was assessed in a case-control test-negative design by comparing cases (PCR-positive for V. cholerae O1) and controls (patients with diarrhoea but PCR-negative) and with the screening method that compared the proportions of vaccinated among cholera cases versus the general fishermen population. Results: Of 145 study participants, 120 were fishermen living on the lake. Vaccine effectiveness at three-months was 90.0% [95%CI:38.8;98.4] among fishermen and 83.3% [95%CI: 20.8; 96.5] among all participants in the case-control test-negative design, and 97.5% [95%CI: 90.9;99.3] with the screening method. Conclusion: This strategy was effective in providing short-term protection in fishermen against cholera. Further research is needed to determine the adding value of the second dose and to identify the optimal vaccination strategies for different contexts.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rightsWith thanks to Elsevier.en_US
dc.subjectCholera
dc.subjectEffectiveness
dc.subjectHard-to-reach populations
dc.subjectMalawi
dc.subjectThermostability
dc.subjectVaccine
dc.titleEffectiveness of oral cholera vaccine in preventing cholera among fishermen in Lake Chilwa, Malawi: A case-control studyen_US
dc.typeArticle
dc.typeOther
dc.identifier.eissn1873-2518
dc.identifier.journalVaccineen_US
dc.source.journaltitleVaccine
dc.source.volume37
dc.source.issue28
dc.source.beginpage3668
dc.source.endpage3676
refterms.dateFOA2020-08-10T18:39:13Z
dc.source.countryInternational
dc.source.countryNetherlands


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