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    Mar 02, 2021
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    Bedaquiline and delamanid for drug-resistant tuberculosis: a clinician's perspective

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    Authors
    Guglielmetti, L
    Chiesi, S
    Eimer, J
    Dominguez, J
    Masini, T
    Varaine, F
    Veziris, N
    Ader, F
    Robert, J
    Issue Date
    2020-07-23
    Submitted date
    2002-09-21
    
    Metadata
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    Journal
    Future Microbiology
    Abstract
    Drug-resistant tuberculosis (TB) represents a substantial threat to the global efforts to control this disease. After decades of stagnation, the treatment of drug-resistant TB is undergoing major changes: two drugs with a new mechanism of action, bedaquiline and delamanid, have been approved by stringent regulatory authorities and are recommended by the WHO. This narrative review summarizes the evidence, originating from both observational studies and clinical trials, which is available to support the use of these drugs, with a focus on special populations. Areas of uncertainty, including the use of the two drugs together or for prolonged duration, are discussed. Ongoing clinical trials are aiming to optimize the use of bedaquiline and delamanid to shorten the treatment of drug-resistant TB.
    Publisher
    Future Medicine
    URI
    http://hdl.handle.net/10144/619734
    Language
    en
    Description
    We regret that this article is behind a paywall.
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    TB

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