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    Jan 25, 2021
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    Clinical perspectives on treatment of rifampicin-resistant/multidrug-resistant TB

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    Cox et al 2020 Clinical perspe ...
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    Authors
    Cox, V
    McKenna, L
    Acquah, R
    Reuter, A
    Wasserman, S
    Vambe, D
    Ustero, P
    Udwadia, Z
    Trivino-Duran, L
    Tommasi, M
    Skrahina, A
    Seddon, JA
    Rodolfo, R
    Rich, M
    Padanilam, X
    Oyewusi, L
    Ohler, L
    Lungu, P
    Loveday, M
    Khan, U
    Khan, P
    Hughes, J
    Hewison, C
    Guglielmetti, L
    Furin, J
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    Issue Date
    2020-11-01
    Submitted date
    2020-12-04
    
    Metadata
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    Journal
    The International Journal of Tuberculosis and Lung Disease
    Abstract
    Rapid diagnostics, newer drugs, repurposed medications, and shorter regimens have radically altered the landscape for treating rifampicin-resistant TB (RR-TB) and multidrug-resistant TB (MDR-TB). There are multiple ongoing clinical trials aiming to build a robust evidence base to guide RR/MDR-TB treatment, and both observational studies and programmatic data have contributed to advancing the treatment field. In December 2019, the WHO issued their second ‘Rapid Communication´ related to RR-TB management. This reiterated their prior recommendation that a majority of people with RR/MDR-TB receive all-oral treatment regimens, and now allow for specific shorter duration regimens to be used programmatically as well. Many TB programs need clinical advice as they seek to roll out such regimens in their specific setting. In this Perspective, we highlight our early experiences and lessons learned from working with National TB Programs, adult and pediatric clinicians and civil society, in optimizing treatment of RR/MDR-TB, using shorter, highly-effective, oral regimens for the majority of people with RR/MDR-TB.
    Publisher
    International Union Against Tuberculosis and Lung Disease
    URI
    http://hdl.handle.net/10144/619787
    Language
    en
    Collections
    TB

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