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    Mar 07, 2021
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    New TB drugs for the treatment of children and adolescents with rifampicin-resistant TB in Mumbai, India

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    Das et al 2020 New TB drugs for ...
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    Authors
    Das, M
    Mamnoon, F
    Mansoor, H
    Meneguim, AC
    Singh, P
    Shah, I
    Ravi, S
    Kalon, S
    Hossain, FN
    Ferlazzo, G
    Isaakidis, P
    Furin, J
    Acharya, S
    Thakur, HP
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    Issue Date
    2020-12-01
    Submitted date
    2021-02-01
    
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    Journal
    The International Journal of Tuberculosis and Lung Disease
    Abstract
    SETTING: Médecins Sans Frontières (MSF) clinic in Mumbai, India. OBJECTIVE: To determine the final treatment outcomes, culture conversion and adverse events (AEs) during treatment among children and adolescents (0–19 years) with rifampicin-resistant tuberculosis (RR-TB) who received ambulatory injectable-free treatment, including bedaquiline (BDQ) and/or delamanid (DLM) during September 2014–January 2020. DESIGN: This was a retrospective cohort study based on review of routinely collected programme data. RESULTS: Twenty-four patients were included; the median age was 15.5 years (min-max 3–19) and 15 (63%) were females. None were HIV-coinfected. All had fluoroquinolone resistance. Twelve received treatment, including BDQ and DLM, 11 received DLM and one BDQ. The median exposure to BDQ (n = 13) and DLM (n = 23) was 82 (IQR 80–93) and 82 (IQR 77–96) weeks, respectively. Seventeen (94%) patients with positive culture at baseline (n = 18) had negative culture during treatment; median time for culture-conversion was 7 weeks (IQR 5–11). Twenty-three (96%) had successful treatment outcomes: cured (n = 16) or completed treatment (n = 7); one died. Eleven (46%) had 17 episodes of AEs. Two of 12 serious AEs were associated with new drugs (QTcF >500 ms). CONCLUSION: Based on one of the largest global cohorts of children and adolescents to receive new TB drugs, this study has shown that injectable-free regimens containing BDQ and/or DLM on ambulatory basis were effective and well-tolerated among children and adolescents and should be made routinely accessible to these vulnerable groups.
    Publisher
    International Union Against Tuberculosis and Lung Disease
    URI
    http://hdl.handle.net/10144/619860
    Language
    en
    Collections
    TB

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