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dc.contributor.authorRamakrishnan, J
dc.contributor.authorSarkar, S
dc.contributor.authorChinnakali, P
dc.contributor.authorLakshiminarayanan, S
dc.contributor.authorSahu, SK
dc.contributor.authorReshma, A
dc.contributor.authorKnudsen, S
dc.contributor.authorDas, M
dc.contributor.authorThekkur, P
dc.contributor.authorVenugopal, V
dc.contributor.authorHochberg, NS
dc.contributor.authorSalgame, P
dc.contributor.authorHorsburgh, CR
dc.contributor.authorEllner, J
dc.contributor.authorRoy, G
dc.date.accessioned2021-07-05T14:58:06Z
dc.date.available2021-07-05T14:58:06Z
dc.date.issued2020-10-01
dc.identifier.issn0019-5707
dc.identifier.pmid33641849
dc.identifier.doi10.1016/j.ijtb.2020.09.022
dc.identifier.urihttp://hdl.handle.net/10144/619942
dc.descriptionWe regret that this article is behind a paywall.en_US
dc.description.abstractObjective Identifying the risk factors for deaths during tuberculosis (TB) treatment is important for achieving the vision of India's National Strategic Plan of ‘Zero Deaths’ by 2025. We aimed to determine the proportion of deaths during TB treatment and its risk factors among smear positive pulmonary TB patients aged more than 15 years. Study design We performed a cohort study using data collected for RePORT India Consortium (Regional Prospective Observational Research in Tuberculosis). Setting Revised TB Control Program (RNTCP) in three districts of South India. Participants The cohort consisted of newly diagnosed drug sensitive patients enrolled under the Revised National TB Control Program during 2014–2018 in three districts of southern India. Information on death was collected at homes by trained project staff. Primary outcome measures We calculated ‘all-cause mortality’ during TB treatment and expressed this as a proportion with 95% confidence interval (CI). Risk factors for death were assessed by calculating unadjusted and adjusted relative risks with 95% CI. Results The mean (SD) age was of the 1167 participants was 45 (14.5) years and 79% of them were males. Five participants (0.4%) were HIV infected. Among the males, 560 (61%) were tobacco users and 688 (75%) reported consuming alcohol. There were 47 deaths (4%; 95% CI 3.0–5.3) of which 28 deaths (60%) occurred during first two months of treatment. In a bi-variable analysis, age of more than 60 years (RR 2.27; 95%CI: 1.24–4.15), male gender (RR 3.98; 95% CI: 1.25–12.70), alcohol use in last 12 months (RR 2.03; 95%CI: 1.07–3.87), tobacco use (RR 1.87; 95%CI: 1.05–3.36) and severe anaemia (RR 3.53: 95%CI: 1.34–9.30) were associated with a higher risk of death. In adjusted analysis, participants with severe anaemia (<7gm/dl) had 2.4 times higher risk of death compared to their counterparts. Conclusion Though deaths during TB treatment was not very high, early recognition of risk groups and targeted interventions are required to achieve zero TB deaths.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectAlcohol
dc.subjectAnaemia
dc.subjectMortality
dc.subjectOperational research
dc.subjectRePORT
dc.titleRisk factors for death during treatment in pulmonary tuberculosis patients in South India: A cohort study.en_US
dc.typeArticle
dc.identifier.journalThe Indian journal of tuberculosisen_US
dc.source.journaltitleThe Indian journal of tuberculosis
dc.source.volume68
dc.source.issue1
dc.source.beginpage32
dc.source.endpage39
dc.source.countryIndia


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