• Login
    View Item 
    •   Home
    • 1 Published Research and Commentary
    • HIV/AIDS
    • View Item
    •   Home
    • 1 Published Research and Commentary
    • HIV/AIDS
    • View Item
    Mar 03, 2021
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of MSFTitleAuthorsSubjectsPublisherJournalThis CollectionTitleAuthorsSubjectsPublisherJournal

    Mortality of patients lost to follow-up in antiretroviral treatment programmes in resource-limited settings: systematic review and meta-analysis

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Brinkhof_ART-LTFU-mort_PLoSONE ...
    Size:
    452.0Kb
    Format:
    PDF
    Description:
    Main article
    Download
    Authors
    Brinkhof, M
    Pujades-Rodriguez, M
    Egger, M
    Affiliation
    Division of International and Environmental Health, Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland; Epicentre, Médecins Sans Frontières, Paris, France; Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    Issue Date
    2009-06-04
    Submitted date
    2009-06-24
    
    Metadata
    Show full item record
    Journal
    PLoS ONE
    Abstract
    BACKGROUND: The retention of patients in antiretroviral therapy (ART) programmes is an important issue in resource-limited settings. Loss to follow up can be substantial, but it is unclear what the outcomes are in patients who are lost to programmes. METHODS AND FINDINGS: We searched the PubMed, EMBASE, Latin American and Caribbean Health Sciences Literature (LILACS), Indian Medlars Centre (IndMed) and African Index Medicus (AIM) databases and the abstracts of three conferences for studies that traced patients lost to follow up to ascertain their vital status. Main outcomes were the proportion of patients traced, the proportion found to be alive and the proportion that had died. Where available, we also examined the reasons why some patients could not be traced, why patients found to be alive did not return to the clinic, and the causes of death. We combined mortality data from several studies using random-effects meta-analysis. Seventeen studies were eligible. All were from sub-Saharan Africa, except one study from India, and none were conducted in children. A total of 6420 patients (range 44 to 1343 patients) were included. Patients were traced using telephone calls, home visits and through social networks. Overall the vital status of 4021 patients could be ascertained (63%, range across studies: 45% to 86%); 1602 patients had died. The combined mortality was 40% (95% confidence interval 33%-48%), with substantial heterogeneity between studies (P<0.0001). Mortality in African programmes ranged from 12% to 87% of patients lost to follow-up. Mortality was inversely associated with the rate of loss to follow up in the programme: it declined from around 60% to 20% as the percentage of patients lost to the programme increased from 5% to 50%. Among patients not found, telephone numbers and addresses were frequently incorrect or missing. Common reasons for not returning to the clinic were transfer to another programme, financial problems and improving or deteriorating health. Causes of death were available for 47 deaths: 29 (62%) died of an AIDS defining illness. CONCLUSIONS: In ART programmes in resource-limited settings a substantial minority of adults lost to follow up cannot be traced, and among those traced 20% to 60% had died. Our findings have implications both for patient care and the monitoring and evaluation of programmes.
    URI
    http://hdl.handle.net/10144/71893
    DOI
    10.1371/journal.pone.0005790
    PubMed ID
    19495419
    Additional Links
    http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0005790
    Type
    Article
    Language
    en
    ISSN
    1932-6203
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pone.0005790
    Scopus Count
    Collections
    HIV/AIDS

    entitlement

    Related articles

    • Self-transfer and mortality amongst adults lost to follow-up in ART programmes in low- and middle-income countries: systematic review and meta-analysis.
    • Authors: Wilkinson LS, Skordis-Worrall J, Ajose O, Ford N
    • Issue date: 2015 Mar
    • Outcomes of HIV-positive patients lost to follow-up in African treatment programmes.
    • Authors: Zürcher K, Mooser A, Anderegg N, Tymejczyk O, Couvillon MJ, Nash D, Egger M, IeDEA and MESH consortia.
    • Issue date: 2017 Apr
    • Loss to programme between HIV diagnosis and initiation of antiretroviral therapy in sub-Saharan Africa: systematic review and meta-analysis.
    • Authors: Mugglin C, Estill J, Wandeler G, Bender N, Egger M, Gsponer T, Keiser O, IeDEA Southern Africa.
    • Issue date: 2012 Dec
    • Retention and mortality on antiretroviral therapy in sub-Saharan Africa: collaborative analyses of HIV treatment programmes.
    • Authors: Haas AD, Zaniewski E, Anderegg N, Ford N, Fox MP, Vinikoor M, Dabis F, Nash D, Sinayobye JD, Niyongabo T, Tanon A, Poda A, Adedimeji AA, Edmonds A, Davies MA, Egger M, African regions of the International epidemiologic Databases to Evaluate AIDS (IeDEA).
    • Issue date: 2018 Feb
    • Correcting mortality for loss to follow-up: a nomogram applied to antiretroviral treatment programmes in sub-Saharan Africa.
    • Authors: Egger M, Spycher BD, Sidle J, Weigel R, Geng EH, Fox MP, MacPhail P, van Cutsem G, Messou E, Wood R, Nash D, Pascoe M, Dickinson D, Etard JF, McIntyre JA, Brinkhof MW, IeDEA East Africa, West Africa and Southern Africa.
    • Issue date: 2011 Jan 18
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.