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    Jan 15, 2021
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    Development of dual-class antiretroviral drug resistance in a child coinfected with HIV and tuberculosis: a case report from KwaZulu-Natal, South Africa.

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    Authors
    Murphy, R A
    France, H
    Sunpath, H
    Gordon, M L
    Marconi, V
    Kuritzkes, D R
    McIntosh, K
    Affiliation
    Massachusetts General Hospital, and Brigham and Women's Hospital, Boston, MA, USA. richard.murphy@newyork.msf.org
    Issue Date
    2009-02
    
    Metadata
    Show full item record
    Journal
    Journal of Tropical Pediatrics
    Abstract
    The treatment of concurrent HIV and tuberculosis (TB) in children <3 years of age has not been well-studied and is complicated by potential drug-drug interactions. The recommended antiretroviral therapy (ART) in coinfected children in South Africa consists of full-strength ritonavir, lamivudine and stavudine. We report on a child initiated on this regimen, during concurrent TB treatment, who promptly developed an adverse reaction, virologic failure and dual-class antiretroviral drug resistance, compromising subsequent salvage ART.
    Publisher
    Published by Oxford University Press
    URI
    http://hdl.handle.net/10144/71895
    DOI
    10.1093/tropej/fmn074
    PubMed ID
    18786985
    Additional Links
    http://tropej.oxfordjournals.org/cgi/content/abstract/55/1/60
    Language
    en
    ISSN
    1465-3664
    ae974a485f413a2113503eed53cd6c53
    10.1093/tropej/fmn074
    Scopus Count
    Collections
    HIV/AIDS

    entitlement

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