Development of dual-class antiretroviral drug resistance in a child coinfected with HIV and tuberculosis: a case report from KwaZulu-Natal, South Africa.
Affiliation
Massachusetts General Hospital, and Brigham and Women's Hospital, Boston, MA, USA. richard.murphy@newyork.msf.orgIssue Date
2009-02
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Journal of Tropical PediatricsAbstract
The treatment of concurrent HIV and tuberculosis (TB) in children <3 years of age has not been well-studied and is complicated by potential drug-drug interactions. The recommended antiretroviral therapy (ART) in coinfected children in South Africa consists of full-strength ritonavir, lamivudine and stavudine. We report on a child initiated on this regimen, during concurrent TB treatment, who promptly developed an adverse reaction, virologic failure and dual-class antiretroviral drug resistance, compromising subsequent salvage ART.Publisher
Published by Oxford University PressPubMed ID
18786985Additional Links
http://tropej.oxfordjournals.org/cgi/content/abstract/55/1/60Language
enISSN
1465-3664ae974a485f413a2113503eed53cd6c53
10.1093/tropej/fmn074
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