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    Jan 19, 2021
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    Dried blood spots are a useful tool for quality assurance of rapid HIV testing in Kigali, Rwanda.

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    Authors
    Chaillet, P
    Zachariah, R
    Harries, K
    Rusanganwa, E
    Harries, A D
    Affiliation
    Médecins sans Frontières, Medical Department, Brussels Operational Center, Belgium.
    Issue Date
    2009-06
    
    Metadata
    Show full item record
    Journal
    Transactions of the Royal Society of Tropical Medicine and Hygiene
    Abstract
    A study was conducted in two primary health facilities in Kigali, Rwanda, to determine whether dried blood spots (DBS) used for quality control of HIV testing would give comparable results with serum after being stored for a period of 14 days and 30 days at ambient temperature. DBS and serum specimens were collected from patients undergoing HIV testing. ELISA performed on serum at baseline (gold standard) was compared with DBS results. The study included a total of 491 patients, comprising 92 (19%) males and 399 (81%) females with a median age of 27 years. A total of 148 individuals (30%) were HIV-positive. The average ambient temperature under which DBS specimens were stored at the health facilities was 23 degrees C (range 18-25 degrees C). The kappa statistic at 14 days and 30 days was 0.99 (99.4% agreement) and 0.98 (99.2% agreement), respectively, signifying almost 'perfect agreement (P<0.001)' with the gold standard. In a resource-limited sub-Saharan African country embarking on scaling-up of HIV testing, DBS stored at ambient conditions for up to 1 month were found to be a useful and robust tool to perform quality control of rapid HIV testing at the health centre level.
    Publisher
    Published by Elsevier
    URI
    http://hdl.handle.net/10144/71897
    DOI
    10.1016/j.trstmh.2009.01.023
    PubMed ID
    19249069
    Additional Links
    http://www.sciencedirect.com/science/journal/00359203
    Language
    en
    ISSN
    0035-9203
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.trstmh.2009.01.023
    Scopus Count
    Collections
    HIV/AIDS

    entitlement

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