Implementation of the thin layer agar for the diagnosis of smear-negative pulmonary tuberculosis in a high HIV prevalence setting in Homa Bay, Kenya.
AffiliationInstitute of Tropical Medicine, Antwerp, Belgium; Médecins Sans Frontières, Paris, France; Homa Bay District Hospital, Kenya.
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JournalJournal of Clinical Microbiology
AbstractThe objective of this study was to evaluate the performance of a low-cost method, the Thin Layer Agar (TLA), for the diagnosis of smear-negative patients. This prospective study was performed in Homa Bay district Hospital in Kenya. Out of 1584 smear-negative sputum samples, 212 were positive by Löwenstein-Jensen (LJ) (13.5%) and 220 positive by TLA (14%). The sensitivity of LJ and TLA was 71% and 74 % respectively. TLA could become an affordable method for the diagnosis of smear-negative tuberculosis in resource-limited settings with results available within 2 weeks.