• Login
    View Item 
    •   Home
    • 1 Published Research and Commentary
    • Malaria
    • View Item
    •   Home
    • 1 Published Research and Commentary
    • Malaria
    • View Item
    Apr 14, 2021
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of MSFTitleAuthorsSubjectsPublisherJournalThis CollectionTitleAuthorsSubjectsPublisherJournal

    Successful introduction of artesunate combination therapy is not enough to fight malaria: results from an adherence study in Sierra Leone.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Gerstl Transactions Successful ...
    Size:
    185.3Kb
    Format:
    PDF
    Download
    Authors
    Gerstl, Sibylle
    Dunkley, Sophie
    Mukhtar, Ahmed
    Baker, Samuel
    Maikere, Jacob
    Affiliation
    Médecins Sans Frontières (MSF) UK, 67-74 Saffron Hill, London EC1N 8QX, UK.
    Issue Date
    2010-02-01
    
    Metadata
    Show full item record
    Journal
    Transactions of the Royal Society of Tropical Medicine and Hygiene
    Abstract
    A study to measure adherence to artesunate and amodiaquine (AS+AQ) therapy in patients treated for uncomplicated malaria in community health centres (CHC) was conducted in Sierra Leone. Patients/caretakers were interviewed and remaining AS+AQ tablets at home after the last treatment dose were counted. Persons leaving CHCs with an AS+AQ prescription were also interviewed (exit interviews). In total, 118 patients were visited at home: 27 (22.9%) had one or more tablets left and were classed as certainly non-adherent; 34 (28.8%) were probably non-adherent [reported incorrect (n=27) or incomplete (n=7) intake]; and 57 (48.3%) were probably adherent. The main reasons for incomplete intake were sickness after one dose of AS+AQ, no food available for drug intake and forgetting to take them. For incorrect intake, reasons were vomiting after drug intake and incorrect instructions given by the CHC. Eighty-one percent of probably adherent patients reported following instructions given to them. In exit interviews, 82% of patients or caretakers of patients were able to repeat AS+AQ intake instructions correctly. Adherence to antimalarial treatment should not be taken for granted. Instructions on correct AS+AQ use should include discussion of disease symptoms as well as possible treatment side effects and how to manage them. Other factors are more difficult to influence, such as patients forgetting to take the treatment.
    URI
    http://hdl.handle.net/10144/98691
    DOI
    10.1016/j.trstmh.2009.12.008
    PubMed ID
    20129636
    Language
    en
    ISSN
    1878-3503
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.trstmh.2009.12.008
    Scopus Count
    Collections
    Malaria

    entitlement

    Related articles

    • Dosing accuracy of artesunate and amodiaquine as treatment for falciparum malaria in Casamance, Senegal.
    • Authors: Brasseur P, Agnamey P, Gaye O, Cisse M, Badiane M, Vaillant M, Taylor WR, Olliaro P
    • Issue date: 2009 Jan
    • Efficacy of combination therapy with artesunate plus amodiaquine compared to monotherapy with chloroquine, amodiaquine or sulfadoxine-pyrimethamine for treatment of uncomplicated Plasmodium falciparum in Afghanistan.
    • Authors: Durrani N, Leslie T, Rahim S, Graham K, Ahmad F, Rowland M
    • Issue date: 2005 Jun
    • Low efficacy of the combination artesunate plus amodiaquine for uncomplicated falciparum malaria among children under 5 years in Kailahun, Sierra Leone.
    • Authors: Grandesso F, Hagerman A, Kamara S, Lam E, Checchi F, Balkan S, Scollo G, Durand R, Guthmann JP
    • Issue date: 2006 Jul
    • Pattern of drug utilization for treatment of uncomplicated malaria in urban Ghana following national treatment policy change to artemisinin-combination therapy.
    • Authors: Dodoo AN, Fogg C, Asiimwe A, Nartey ET, Kodua A, Tenkorang O, Ofori-Adjei D
    • Issue date: 2009 Jan 5
    • High adherence to malaria treatment: promising results of an adherence study in South Kivu, Democratic Republic of the Congo.
    • Authors: Gerstl S, Namagana A, Palacios L, Mweshi F, Aprile S, Lima A
    • Issue date: 2015 Oct 19
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.