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    Apr 17, 2021
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    Multiple origins and regional dispersal of resistant dhps in African Plasmodium falciparum malaria.

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    Authors
    Pearce, Richard J
    Pota, Hirva
    Evehe, Marie-Solange B
    Bâ, El-Hadj
    Mombo-Ngoma, Ghyslain
    Malisa, Allen L
    Ord, Rosalynn
    Inojosa, Walter
    Matondo, Alexandre
    Diallo, Diadier A
    Mbacham, Wilfred
    van den Broek, Ingrid V
    Swarthout, Todd D
    Getachew, Asefaw
    Dejene, Seyoum
    Grobusch, Martin P
    Njie, Fanta
    Dunyo, Samuel
    Kweku, Margaret
    Owusu-Agyei, Seth
    Chandramohan, Daniel
    Bonnet, Maryline
    Guthmann, Jean-Paul
    Clarke, Sian
    Barnes, Karen I
    Streat, Elizabeth
    Katokele, Stark T
    Uusiku, Petrina
    Agboghoroma, Chris O
    Elegba, Olufunmilayo Y
    Cissé, Badara
    A-Elbasit, Ishraga E
    Giha, Hayder A
    Kachur, S Patrick
    Lynch, Caroline
    Rwakimari, John B
    Chanda, Pascalina
    Hawela, Moonga
    Sharp, Brian
    Naidoo, Inbarani
    Roper, Cally
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    Affiliation
    London School of Hygiene & Tropical Medicine, Department of Infectious Tropical Diseases, London, UK.
    Issue Date
    2009-04-14
    
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    Journal
    PLoS Medicine
    Abstract
    BACKGROUND: Although the molecular basis of resistance to a number of common antimalarial drugs is well known, a geographic description of the emergence and dispersal of resistance mutations across Africa has not been attempted. To that end we have characterised the evolutionary origins of antifolate resistance mutations in the dihydropteroate synthase (dhps) gene and mapped their contemporary distribution. METHODS AND FINDINGS: We used microsatellite polymorphism flanking the dhps gene to determine which resistance alleles shared common ancestry and found five major lineages each of which had a unique geographical distribution. The extent to which allelic lineages were shared among 20 African Plasmodium falciparum populations revealed five major geographical groupings. Resistance lineages were common to all sites within these regions. The most marked differentiation was between east and west African P. falciparum, in which resistance alleles were not only of different ancestry but also carried different resistance mutations. CONCLUSIONS: Resistant dhps has emerged independently in multiple sites in Africa during the past 10-20 years. Our data show the molecular basis of resistance differs between east and west Africa, which is likely to translate into differing antifolate sensitivity. We have also demonstrated that the dispersal patterns of resistance lineages give unique insights into recent parasite migration patterns.
    URI
    http://hdl.handle.net/10144/98755
    DOI
    10.1371/journal.pmed.1000055
    PubMed ID
    19365539
    Language
    en
    ISSN
    1549-1676
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pmed.1000055
    Scopus Count
    Collections
    Malaria

    entitlement

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