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    Feb 24, 2021
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    Factors Associated with Marburg Hemorrhagic Fever:

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    Roddy - Factors Associated with ...
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    Major Article
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    Authors
    Roddy, Paul
    Sara L Thomas
    Benjamin Jeffs
    Pascoal Nascimento Folo
    Pedro Pablo Palma
    Bengi Moco Henrique
    Luis Villa
    Fernando Paixao Damiao Machado
    Oscar Bernal
    Steven M. Jones
    James E. Strong
    Heinz Feldmann
    Matthias Borchert
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    Affiliation
    Medecins Sans Frontieres–Spain and others
    Issue Date
    2010-06-15
    Submitted date
    2009-06-15
    
    Metadata
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    Journal
    The Journal of Infectious Diseases
    Abstract
    Background. Reliable on-site polymerase chain reaction (PCR) testing for Marburg hemorrhagic fever (MHF) is not always available. Therefore, clinicians triage patients on the basis of presenting symptoms and contact history. Using patient data collected in Uige, Angola, in 2005, we assessed the sensitivity and specificity of these factors to evaluate the validity of World Health Organization (WHO)–recommended case definitions for MHF. Methods. Multivariable logistic regression was used to identify independent predictors of PCR confirmation of MHF. A data-derived algorithm was developed to obtain new MHF case definitions with improved sensitivity and specificity. Results. A MHF case definition comprising (1) an epidemiological link or (2) the combination of myalgia or arthralgia and any hemorrhage could potentially serve as an alternative to current case definitions. Our dataderived case definitions maintained the sensitivity and improved the specificity of current WHO-recommended case definitions. Conclusions. Continued efforts to improve clinical documentation during filovirus outbreaks would aid in the refinement of case definitions and facilitate outbreak control.
    Publisher
    Infectious Disease Society of America
    URI
    http://hdl.handle.net/10144/99154
    DOI
    10.1086/652748
    Type
    Article
    Language
    en
    ISSN
    00221899
    15376613
    ae974a485f413a2113503eed53cd6c53
    10.1086/652748
    Scopus Count
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