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Roddy - Factors Associated with ...
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Major Article
Authors
Roddy, PaulSara L Thomas
Benjamin Jeffs
Pascoal Nascimento Folo
Pedro Pablo Palma
Bengi Moco Henrique
Luis Villa
Fernando Paixao Damiao Machado
Oscar Bernal
Steven M. Jones
James E. Strong
Heinz Feldmann
Matthias Borchert
Affiliation
Medecins Sans Frontieres–Spain and othersIssue Date
2010-06-15Submitted date
2009-06-15
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Background. Reliable on-site polymerase chain reaction (PCR) testing for Marburg hemorrhagic fever (MHF) is not always available. Therefore, clinicians triage patients on the basis of presenting symptoms and contact history. Using patient data collected in Uige, Angola, in 2005, we assessed the sensitivity and specificity of these factors to evaluate the validity of World Health Organization (WHO)–recommended case definitions for MHF. Methods. Multivariable logistic regression was used to identify independent predictors of PCR confirmation of MHF. A data-derived algorithm was developed to obtain new MHF case definitions with improved sensitivity and specificity. Results. A MHF case definition comprising (1) an epidemiological link or (2) the combination of myalgia or arthralgia and any hemorrhage could potentially serve as an alternative to current case definitions. Our dataderived case definitions maintained the sensitivity and improved the specificity of current WHO-recommended case definitions. Conclusions. Continued efforts to improve clinical documentation during filovirus outbreaks would aid in the refinement of case definitions and facilitate outbreak control.Publisher
Infectious Disease Society of AmericaDOI
10.1086/652748Type
ArticleLanguage
enISSN
0022189915376613
ae974a485f413a2113503eed53cd6c53
10.1086/652748