Show simple item record

dc.contributor.authorRoddy, Paul*
dc.contributor.authorSara L Thomas*
dc.contributor.authorBenjamin Jeffs*
dc.contributor.authorPascoal Nascimento Folo*
dc.contributor.authorPedro Pablo Palma*
dc.contributor.authorBengi Moco Henrique*
dc.contributor.authorLuis Villa*
dc.contributor.authorFernando Paixao Damiao Machado*
dc.contributor.authorOscar Bernal*
dc.contributor.authorSteven M. Jones*
dc.contributor.authorJames E. Strong*
dc.contributor.authorHeinz Feldmann*
dc.contributor.authorMatthias Borchert*
dc.date.accessioned2010-05-18T15:26:34Z
dc.date.available2010-05-18T15:26:34Z
dc.date.issued2010-06-15
dc.date.submitted2009-06-15
dc.identifier.citationRoddy P, Thomas SL, Jeffs B, et al. Factors associated with Marburg hemorrhagic fever: analysis of patient data from Uige, Angola. Journal of Infectious Diseases. 2010;201(12)1909-1918en
dc.identifier.issn00221899
dc.identifier.issn15376613
dc.identifier.doi10.1086/652748
dc.identifier.urihttp://hdl.handle.net/10144/99154
dc.description.abstractBackground. Reliable on-site polymerase chain reaction (PCR) testing for Marburg hemorrhagic fever (MHF) is not always available. Therefore, clinicians triage patients on the basis of presenting symptoms and contact history. Using patient data collected in Uige, Angola, in 2005, we assessed the sensitivity and specificity of these factors to evaluate the validity of World Health Organization (WHO)–recommended case definitions for MHF. Methods. Multivariable logistic regression was used to identify independent predictors of PCR confirmation of MHF. A data-derived algorithm was developed to obtain new MHF case definitions with improved sensitivity and specificity. Results. A MHF case definition comprising (1) an epidemiological link or (2) the combination of myalgia or arthralgia and any hemorrhage could potentially serve as an alternative to current case definitions. Our dataderived case definitions maintained the sensitivity and improved the specificity of current WHO-recommended case definitions. Conclusions. Continued efforts to improve clinical documentation during filovirus outbreaks would aid in the refinement of case definitions and facilitate outbreak control.
dc.language.isoenen
dc.publisherInfectious Disease Society of Americaen
dc.rightsPublished by Infectious Diseases Society of America Archived on this site with permission and copyright 2010 by the Infectious Diseases Society of America, [url]http://www.journals.uchicago.edu/toc/jid[/url]en
dc.subjectfilovirusen
dc.subjectcase definitionen
dc.titleFactors Associated with Marburg Hemorrhagic Fever:en
dc.typeArticleen
dc.contributor.departmentMedecins Sans Frontieres–Spain and othersen
dc.identifier.journalThe Journal of Infectious Diseasesen
refterms.dateFOA2019-03-04T15:40:51Z
html.description.abstractBackground. Reliable on-site polymerase chain reaction (PCR) testing for Marburg hemorrhagic fever (MHF) is not always available. Therefore, clinicians triage patients on the basis of presenting symptoms and contact history. Using patient data collected in Uige, Angola, in 2005, we assessed the sensitivity and specificity of these factors to evaluate the validity of World Health Organization (WHO)–recommended case definitions for MHF. Methods. Multivariable logistic regression was used to identify independent predictors of PCR confirmation of MHF. A data-derived algorithm was developed to obtain new MHF case definitions with improved sensitivity and specificity. Results. A MHF case definition comprising (1) an epidemiological link or (2) the combination of myalgia or arthralgia and any hemorrhage could potentially serve as an alternative to current case definitions. Our dataderived case definitions maintained the sensitivity and improved the specificity of current WHO-recommended case definitions. Conclusions. Continued efforts to improve clinical documentation during filovirus outbreaks would aid in the refinement of case definitions and facilitate outbreak control.


Files in this item

Thumbnail
Name:
Roddy - Factors Associated with ...
Size:
376.5Kb
Format:
PDF
Description:
Major Article

This item appears in the following Collection(s)

Show simple item record